2024 - Kidney Research Impact Report - Flipbook - Page 9
Urinary interleukin-9 in youth with type 1 diabetes mellitus: The cytokine interleukin-9 (IL-9 reduces injury to the glomerular
cell “podocyte” in experimental kidney disease. Here, Dr. Burger and colleagues analysed urine samples and clinical data from
youth with type 1 diabetes and found that urinary levels of IL-9 were inversely related to levels of podocyte extracellular vesicles
(EVs. The results suggest that IL-9 may decrease podocyte injury in early type 1 diabetes in humans.
Impact of acute moderate-intensity aerobic exercise on circulating extracellular vesicles in pregnant and non-pregnant
women: This study assessed the e昀昀ect of aerobic exercise on blood levels of large extracellular vesicles (EVs in pregnant
versus non-pregnant women. Interestingly, non-pregnant women demonstrated a decrease in blood vessel-derived EV level
after acute exercise, but this e昀昀ect was not seen in pregnant women. The reasons for this di昀昀erence remain unclear and require
further research.
Performance of the 2021 Race-Free CKD-EPI Creatinine- and Cystatin C-Based Estimated GFR Equations Among
Kidney Transplant Recipients: Previous estimates of kidney function (estimated glomerular 昀椀ltration rate, eGFR have been
based on mathematical equations that include correction factors based on race. In 2021, “race-free” equations incorporating
creatinine with and without cystatin C were developed and recommended for routine use. Whether these equations apply to
kidney transplant recipients is unclear. In this important study of 415 kidney transplant recipients from Canada and New Zealand,
Drs. Hundemer, Akbari, and colleagues showed that the 2021 race-free eGFR equations perform similarly to the previous
equations that included race correction terms.
The Risk of Cardiovascular Events in Individuals With Primary Glomerular Diseases: Patients with chronic kidney disease
are known to be at high risk of cardiovascular disease. Cardiovascular risk in patients with primary glomerular diseases is
poorly understood because these conditions are rare and require a kidneybiopsy for diagnosis. In this study of 1,912 Canadian
patients with biopsy-proven IgA nephropathy, minimal change disease, focal segmental glomerulosclerosis, and membranous
nephropathy, the rate of cardiovascular events was 2.5 times higher than in the general population and was high for each disease
type. Consideration of disease type, kidney function, and proteinuria improved the prediction of cardiovascular events.
Predictors of serum vancomycin levels in peritoneal dialysis-associated peritonitis:
Intraperitoneal (IP vancomycin is often 昀椀rst-line therapy for peritoneal dialysis (PD peritonitis; however, optimal dosing remains
unclear. This was a study of 58 adult patients with PD peritonitis treated with IP vancomycin. Surprisingly, despite receiving 2-g
vancomycin loading dose for suspected PD peritonitis, one-third of the patients had sub-therapeutic levels of vancomycin on day
3. The authors conclude that consideration of residual kidney function and weight-based dosing could improve the likelihood of
achieving an early therapeutic level.
The Ottawa Hospital | Kidney Research Centre
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