Sysmex 2024 Fall Newsletter - Flipbook - Page 13
Fall 2024
Another of the RBC indices, mean corpuscular hemoglobin
concentration (MCHC), indicates the average amount of hemoglobin in
each red blood cell relative to its volume. Normal MCHC values typically
range from 32 to 36 g/dL. When the MCHC is < 32 g/dL, cells are usually
considered hypochromic and may display a larger than normal central
pallor when viewed on a stained peripheral blood smear (Figure 1).
Hypochromia is commonly associated with IDA, but may also be seen in
thalassemia and/or anemia of chronic diseases. However, hyperchromia
is uncommon and not generally associated with a speci昀椀c anemia.
Advanced RBC parameters
Hemoglobin concentration and morphological RBC classi昀椀cation
provide valuable clinical insights into anemia status, especially if iron or
vitamin de昀椀ciencies are involved. Hence, ef昀椀cient medical intervention
depends on precise differential diagnosis. In addition to RBC indices,
Sysmex’s XN-Series™ and select XN-L Series™ analyzers provide
advanced RBC parameters that can assist clinicians in assessing
patients with anemia. A dedicated reticulocyte channel on these
analyzers provides the additional Immature Reticulocyte Fraction (IRF)
and Reticulocyte Hemoglobin Equivalent (RET-He) parameters that
supply information about the rate of RBC production and hemoglobin
content in the newly formed reticulocytes, respectively. This additional
information may help physicians determine the cause of anemia and/or
monitor treatment of their patients.
IMPORTANT REMINDER FOR
XE-SERIES™
AND XT-SERIES™
USERS
This is a reminder that the XE-Series and
XT-Series Hematology Analyzers will no
longer be serviced or supported by Sysmex
as of December 31, 2024. After this date,
customers will not be able to order:
• QC material
• Reagents
• Spare parts
• Consumables
Figure 1:
Hypochromic RBCs
displaying large
central pallor.
Phone and Field support will also be
discontinued.
Per Product Noti昀椀cation 62-1712, the
targeted end of support date was August
31, 2023. After that time, continuation of
support for the XE and XT was extended
on a case-by-case basis. Note that these
models will no longer be supported after
Dec. 31, 2024 regardless of prior agreement.
Resources
Guideline on haemoglobin cutoffs to de昀椀ne anaemia in individuals and populations.
World Health Organization. August 2, 2024. https://www.who.int/publications/i/
item/9789240088542
1
Please contact your Sysmex sales
representatives to discuss our latest
offerings for your hematology lab or visit
www.sysmex.com to learn more about our
laboratory solutions.
NEWS |
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