ID-5184 Wonca Abstracts supplement A-K 13-10-23 - Flipbook - Page 170
WONCA 2023 Supplement 1: WONCA 2023 abstracts (A–K)
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Profile of breakthrough infection of COVID-19 in a tertiary
care hospital: A descriptive cross-sectional study
Dr Bishwa Dawadi1, Khilasa Pokharel
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Kathmandu Medical College
Background
While reports of vaccine-induced immunity against COVID-19 have been around, frequency of
breakthrough infections is also being reported. The study aimed to analyse breakthrough infections
after a complete dose of COVID-19 vaccination.
Methods
Individuals who were fully vaccinated with COVID-19 were included in this study. Nasopharyngeal and
oropharyngeal swabs were collected and transported to the laboratory as soon as possible for the
diagnosis of COVID-19. The specimens were transported in a viral transport medium maintaining a
cold chain of 2–8°C. Statistical Package for the Social Sciences (SPSS) version 20 was used for data
entry and analysis.
Results
Of 8350 samples received, 5494 (65.79%) were vaccinated and 2856 (34.20%) were not vaccinated.
Among fully vaccinated individuals, 694 (12.63%) are post-vaccination COVID-19 cases. Among the
post-vaccinated COVID-19 cases, 264 (14.15%), 95 (12.70%), 44 (3.19%) and 28 (1.86%) breakthrough
infections were seen among individuals who received Sinopharm, Oxford-AstraZeneca, Johnson and
Johnson, other vaccines Pfizer, Moderna, Sputnik V respectively which were tested positive for SARSCoV-2 RNA on reverse transcriptase polymerase chain reaction.
Conclusions
Laboratory-confirmed COVID-19 cases among vaccinated individuals after complete dose of
vaccination indicates that there is still risk of COVID-19. Therefore, regular COVID-19 testing should be
conducted even after vaccination.
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