ID-5184 Wonca Abstracts supplement A-K 13-10-23 - Flipbook - Page 139
WONCA 2023 Supplement 1: WONCA 2023 abstracts (A–K)
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Gender difference in the association between cystatin
C-to-creatine ratio (CCR) and metabolic syndrome in
healthy Chinese adults
Dr Jo-hsuan Chen, Wencheng Li, Jau-Yuan Chen
The Department of Family Medicine, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan City
Aim
To investigate the gender difference in the association between serum cystatin C-to-creatinine (CCR)
and metabolic syndrome (MetS) in healthy Chinese adults.
Method
A cross-sectional study was conducted at Xiamen Chang Gung Hospital from 2014 to 2016 on 10,054
participants over 18 years of age who underwent clinical and biochemical exams, including past
medical history, height, weight, waistline, blood pressure, total cholesterol, LDL-C, HDL-C, triglyceride,
fasting blood glucose, serum creatine and serum cystatin C. Participants were divided into genderspecific quartiles according to CCR. MetS was adjusted into difference models. The data were
analysed by using Chi-squared tests, the Cochran-Armitage test for trend and logistic regression to
explore the relationship between cardiometabolic risk factors and MetS.
Result
In all, 9854 Chinese adults, including 5638 males and 4416 females (mean age 47.5 ± 10.4 years),
were eligible for analysis. MetS was present in 25.5% of males and 18.7% of females. Significant
differences were observed in both genders between MetS and CCR quartiles in the trend test. Males
showed significant differences between CCR quartiles with age, waist-to-height ratio, TG/HDL-C, but
not with mean arterial pressure and triglycerides. In females, significant difference is demonstrated in
all variables. After adjustment for age, fasting glucose, TG, HDL-C and LDL-C, there were no significant
differences between any CCR quartile and MetS in males. This indicates that as more factors were
adjusted, the correlation was presented less. In females, however, CCR had a positive significant
association with MetS, especially in CCR quartile 4 (OR 1.88; 95% CI: 1.31, 2.70).
Conclusion
Our study suggests that a high CCR level is an independent risk factor for MetS in females.
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