ID-5184 Wonca Abstracts supplement A-K 13-10-23 - Flipbook - Page 138
WONCA 2023 Supplement 1: WONCA 2023 abstracts (A–K)
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Evaluation of the effect of lifestyle intervention on nonobese patients with non-alcoholic fatty liver disease
Jing Chen
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南方医科大学第七附属医院
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Introduction
Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease with a global prevalence of
about 25%. About 10–20% of NAFLD patients are not obese. This study aims to evaluate the efficacy
of lifestyle intervention in non-obese NAFLD patients.
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Methods
One hundred NAFLD patients over 18 years old in Shayuan Community were randomly divided into
a study group and a control group, with 50 patients in each group. The study group underwent a
12-month lifestyle intervention program, including regular exercise and dietary guidance. The control
group received routine outpatient follow-up management. The main outcome was to compare the
laboratory indicators (fasting blood glucose, total cholesterol, triglyceride, low-density lipoprotein),
proton magnetic resonance spectroscopy, knowledge of prevention and treatment of non-alcoholic
fatty liver, and treatment compliance of fatty liver between the two groups before and after intervention
through 12 months of follow-up and management.
Results
After the lifestyle intervention management mode, the fasting blood glucose, total cholesterol,
triglyceride and low-density lipoprotein of patients were lower than before the intervention, the
awareness rate of patients and their families of NAFLD in the study group was higher than before the
intervention and the compliance behaviour of patients in the study group was higher than before the
intervention. Lifestyle intervention can effectively treat NAFLD in non-obese patients.
Discussion
Lifestyle interventions are central to the management of NAFLD, and both dietary interventions and
exercise programs have been shown to improve liver fat and histological severity in patients with
NAFLD. In this randomised controlled trial, a lifestyle intervention program was effective in treating
NAFLD in non-obese patients.
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