Hollings Annual Report 2023 FINAL - Flipbook - Page 13
of prostate cancer that doctors are familiar with or how it
might affect standard treatments.
Deshmukh teamed up with collaborators at Icahn School of
Medicine at Mount Sinai and The University of Texas MD
Anderson Cancer Center to model the effects of HIV and
HIV treatment on prostate cancer.
The trio received a $3.4 million grant from the National
Cancer Institute to develop guidance on optimal ways to
manage prostate cancer among people with HIV.
GVHD biomarkers
2023 Research
by the numbers
311
50
high-impact publications
83
NCI awards
$15.0M
166
$26.3M
Blood cancer patients receiving stem cells from a donor
face the possibility of a common side effect – graft-versushost-disease (GVHD), in which the donated cells begin
attacking the patient’s own healthy cells. Chronic GVHD
ranges from mild to severe; unfortunately, it can be quite
debilitating and is a major cause of death for patients.
Treatments for chronic GVHD are improving, but it is so
prevalent that there is still a strong need to identify patients
at most risk of developing this condition so it can be caught
and treated early, said Sophie Paczesny, M.D., Ph.D.
Paczesny led a multicenter team that reported in the
Journal of Clinical Investigation that it’s identified three
risk biomarkers that could be measured at 90 days after
transplantation, long before a doctor would be able to
make a clinical diagnosis of chronic GVHD.
Paczesny said the next step would be to create an algorithm
with a cut-off score designating who should be considered
high risk and then to move this into a clinical trial providing
preemptive treatment to those who test as high risk.
Celebrating 30 Years
publications
(Impact Factor > 10)
NCI funding
peer-reviewed awards
peer-reviewed funding
12
new members
cbi
Scott Eblen, Ph.D.
cbi
Lu Han, Ph.D.
cbi
Judit Jiménez-Sainz, Ph.D.
cbi
Martin Kang, Ph.D.
cbi
Casey Langdon, Ph.D.
cbi
Souvik Seal, Ph.D.
cbi
Ben Strickland, M.D.
cPC
Hazel Breland, Ph.D.
cPC
Kathryn Engelhardt, M.D.
cPC
Joni Nelson, Ph.D.
DcT
Thai Ho, M.D., Ph.D.
DcT
Kevin Roggin, M.D.
11
