MBRF Organizational Brochure - Flipbook - Page 9
The McKnight Brain Institutes
Methods applied to understanding the mechanisms of
brain aging that underly cognitive change with aging
include state-of-the-art ensemble electrophysiological
recording in behaving animals that can monitor
changes in brain networks and cognitive decline in
aged rodents and nonhuman primates and can be
combined with live imaging methodologies. Other
large-scale molecular imaging technologies are also
used (the catFISH method) that allow the examination
of individual cells that participate in circuits critical for
memory. Genetic, proteomic and epigenetic methods
are also used by the EMBI researchers at the University
of Arizona, and, in collaboration with our colleagues
at the other McKnight Brain Institutes, to understand
changes in molecular pathways that control cell function
and are critical for brain plasticity mechanisms. The
Evelyn F. McKnight Brain Institute in Tucson also shares
and develops sophisticated methods for collection
of functional and structural MRI data in humans, and
is a leader in developing machine learning and other
advanced approaches for analyses of these data.
40+
affiliate faculty spanning 21
departments and 5 colleges
200+
articles published annually
on topics related to aging
$
29M
in research funding
Learn more about the UA MBI
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