Nboost Doctor brochure - Flipbook - Page 16
Observed effects: Preventative benefits1
KERATIN 10
% change after 28 days of Nboost treatment:
THICKNESS OF THE EPIDERMIS
THICKNESS
OF
EPIDERMIS
10%
20% THE
30%
40%
50%
0%
0%
5.6% MONOTHERAPY
5.6% SECTUM
MONOTHERAPY
12.0%
12.0%
10%
20%
SECTUM
30%
40%
50%
60%
60%
DENSITY OF THE EPIDERMIS
DENSITY
THE EPIDERMIS
10% OF20%
30%
40%
0%
0%
7.1% MONOTHERAPY
7.1% SECTUM
MONOTHERAPY
10%
20%
SECTUM
30%
40%
Nboost
vs control
+113%
Nboost improves epidermal
thickness and density to
temporally correct the soft
tissue deficit
50%
60%
50%
60%
57.7%
57.7%
control
Nboost
vs Sectum
+55%
KERATIN 17
Results measured by HF ultrasound imageing device.
Nboost
vs control
- no change
Nboost
vs control
+107%
Nboost
vs Sectum
+53%
control
control
control
control
control
control
boost
Ki-67 protein is present during all active phases of the cell
cycle (G1, S, G2, and mitosis), but is absent from resting cells
(G0), making it an excellent marker for determining the socalled growth fraction of a given cell population2.
Nboost contributes to induce mechanical stress3, causing
biochemical changes in skin physiology which helps to
maintain the skin homeostasis and supports regeneration
Anna Płatkowska-Szczerek, Simultaneous use of non-cross-linked hyaluronic acid and radiofrequency in patients with laxity and dry facial skin, Anclara Health & Aesthetics, Warsaw, Poland, 2021
Scholzen T, Gerdes J. The Ki-67 protein: from the known and the unknown. J Cell Physiol. 2000 Mar;182(3):311-22. doi: 10.1002/(SICI)1097-4652(200003)182:3
3.0.CO;2-9. PMID:
10653597. 3 Mei-fang Wang a , Jun-ying Zhaoa , and Lin-feng Lia; Evaluation of changes in skin biophysical parameters and appearance after pneumatic injections of non-cross-linked hyaluronic
acid in the face; JOURNAL OF COSMETIC AND LASER THERAPY 2018, VOL. 20, NOS. 7–8, 454–461. 4 Wallace L, Roberts-Thompson L, Reichelt J. Deletion of K1/K10 does not impair epidermal
stratification but affects desmosomal structure and nuclear integrity. J Cell Sci. 2012 Apr 1;125(Pt 7):1750-8. doi: 10.1242/jcs.097139. Epub 2012 Feb 28. PMID: 22375063. 5 Zhang X, Yin M, Zhang LJ.
Keratin 6, 16 and 17-Critical Barrier Alarmin Molecules in Skin Wounds and Psoriasis. Cells. 2019 Aug 1;8(8):807. doi: 10.3390/cells8080807. PMID: 31374826; PMCID: PMC6721482.
1
2
Nboost
vs Sectum
- no change
boost
In addition to their well-established function in providing epidermal
stability, Keratin 10 intermediate filaments are supposed to be important
for terminal epidermal differentiation and barrier formation4.
Nboost helps to prevent thinning of the skin and form an efficient
epidermal barrier
Keratin 17 is recognized as key early barrier alarmins and its upregulation
contributes to hyperproliferation and innate immune activation of KCs in
response to an epidermal barrier breach, followed by the autoimmune
activation of T cells5. No change was observed in Keratin 17 which
would indicate an immune response
