Brochure Fillers - Flipbook - Page 13
From
unique properties
▶ U nique
t o u n i q u e pat i e n t o u t c o m e s
Prof. Nicola Zerbinati
Dermatologist and Aesthetic Medicine Specialist, Neauvia Scientific Director,
President of the Italian Federation of Aesthetic Medicine (FIME),
Scientific coordinator of ICAM USA
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They are able to regulate the water diffusion
process inside the hydrogel, preventing an
excessive swelling and helping in mitigating
Glycine and L-Proline are natural amino
water stress while balancing turgor pressure
acids with multiple physiological roles in the
during stress. Glycine and L-Proline also
human body, including collagen formation.
play an important role in the control of
They are added to NEAUVIA hydrogels in
cell volume and osmoregulation as they
a concentration of approximately 0,1% in
keeps the structure of the hydrogel constant
order to improve the rheological properties
and prevents uncontrolled swelling. The
and the swelling resistance.
addition of this two amino acids in Neauvia
formulation ensures a better control of the
1_Polymers mesh | 2_Safe Crosslinker
Indeed, the ability of cross-linked HA
hydrogel swelling capacity in the post-
to absorb water arises from hydrophilic
implant phase.
functional groups attached to the polymer
3_Specific Rheological Properties
backbone, while its resistance to dissolution
At the same time, Proline and Glycine
arises from cross-links between network
guarantee hydration and give softness to
6_Advanced delivery system
chains. Water inside the hydrogel allows free
the skin tissue, acting as humectant and
diffusion of some solute molecules, while the
emollient, respectively.
polymer serves as a matrix to hold water
lead to their choice for the stabilization of
together.
the structure of the hydrogel, especially
7_Thermo-stability | 8_Permeability
*Data on file. NEAUVIA Scientific Publications on
www.neauvia.com/publications
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GLYCINE AND
L-PROLINE
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FOCUS ON
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PEG is giving NEAUVIA hydrogels unique properties that make
our synergistic approach through combined protocols possible.
First, this immuno-modulatory effect that has been demonstrated in-vitro and in-vivo.
And secondly, this high resistance to both the enzymatic degradation and to heat.
rheological properties
for high performance 1
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All these factors
in terms of viscoelastic properties and
thermodynamic balance.4
Zerbinati, N.; Sommatis, S.; Maccario, C.; Capillo, M.C.; Grimaldi, G.; Alonci, G.; Protasoni, M. Rauso, R.; Mocchi, R. Toward Physicochemical
and Rheological Characterization of Different HA Dermal Fillers Cross-Linked with Polyethylene Glycol Diglycidyl Ether. Polymers 2021, 13, 948.
2
Raffaele Rauso, Giovanni Francesco Nicoletti, Pierfrancesco Bove, Giuseppe M. Rauso, Romolo Fragola, Giorgio Lo Giudice, Nicola Zerbinati,
Clinical Experience with PEGylated Hyaluronic Acid Fillers: A 3-year Retrospective Study, Open Access Macedonian Journal of Medical
Sciences. 2021 Oct 14; 9(B):1168-1173.
3
Nicola Zerbinati, Hassan Ibrahim Galadari, Paweł Kubik, Sergey Ivanov, Neauvia Symposium - Holistic approach in treating mid-face.
Neauvia Smart Combination Therapy (SCT) - Data on file.
4
V Martina , A Gallo, E Tarantino, C Esposito, U Zerbinati, R Mocchi , D Monticelli , T Lotti , M Tirant , N Van Thuong , R Rauso , N Zerbinati ;
Viscoelastic properties and thermodynamic balance improvement of a hyaluronic acid hydrogel enriched with proline and glycine; J Biol
Regul Homeost Agents . Nov-Dec 2019;33(6):1955-1959. doi: 10.23812/19-252-L.
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