ORCHID Annual Report 2023 - Flipbook - Page 24
normal cells) using three DNA markers. We want to see if the presence of these markers is enough or if the
markers have to reach a certain level for the disease to come back.
2) The secondary objective is to compare results for peripheral blood and bone marrow to see if blood
analysis alone can indicate early relapse, leading to a reduction of bone marrow samples being taken and a
reduction in the number of hospital stays and costs.
3) The third objective is to develop a riskstratification framework guiding proactive therapeutic interventions.
Based on the results a framework will be developed to provide future guidance to doctors who treat JMML
patients nationally.
Project Updates
I have completed the first year of the NIHR DCAF fellowship. This included developing and validating
the digital droplet PCR method for microchimerism analysis. All patient samples (retrospective cohort)
have now been processed for chimerism and microchimerism analysis. I9m currently in the process of
analysing the data and provide the first statistically relevant findings. I have enrolled on the BBTS Stem
Cell Transplantation Science course as part of my formal study for the DCAF fellowship.
Digital profile:
ORCiD ID: 0000-0003-0791-2291
Peer reviewed Publications:
Adams S, Hancock J, Kaplinsky J, Sosinsky A, Wright G, Gkazi AS, Kricke S, Thomas R, Kent N,
Hodder A, Bartram J. (2023) Routine Whole Genome Sequencing Offers a More Comprehensive
Assessment of IG/TCR Gene Rearrangements for MRD Targets in Acute Lymphoblastic Leukemia Data from the First 62 Cases from the NHS England Genomic Medicine Service, Blood, 142,
(Supplement 1)4351, ISSN 0006-4971, doi:10.1182/blood-2023-187667
Invited talks:
Kricke S. Preliminary project data at the UK & Ireland Paediatric Bone Marrow Transplant Group Spring
Meeting, Hallam Conference Centre, London, 23rd May 2023.
Kricke S. 'Research, the NHS and You: NIHR Conference for people new to research' & 'How can I
access clinical research training in my service role?' NIHR Research conference, Excel London,
21st September 2023
Kricke S. 'Early Relapse Detection in JMML patients post BMT' -10th International Symposium on
Myelodysplasia and Severe Aplastic Anaemia in Childhood, Lisbon, Portugal, 29th September 2023
Awards:
Kricke S. GOSH Staff 8Research Hospital Award9, September 2023
Alex Stewart
MRes, BSc
University College London, NIHR Fellowship
Study title: SaFE - A Mixed Methods Exploration of Swallowing, Feeding and Eating in Children Born with
Oesophageal Atresia and/or Trachea-Oesophageal Fistula (OA/TOF)
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