ORCHID Annual Report 2023 - Flipbook - Page 21
(pharmacokinetics), the dose required to reach the desired effects remains unknown, causing adverse
effects and treatment failures. Population pharmacokinetic models use mathematical (statistical) models to
evaluate data from all individuals in a population simultaneously to describe the drug handling properties
and factors that causes difference in drug handling between individuals. Using these models, the dosage
can be personalised based on patient characteristics, such as age groups, organ function, disease state and
even pharmacogenetic information. It allows management to move away from a
