Master ReVasca Monograph 6.2.24 - Paper - Page 7
REVASCA™ PHYSICIAN MONOGRAPH
— ReVasca™ Ingredients —
A human study in 48 athletes ages 35-45 reported
ViNitrox® polyphenols can help improve physical
endurance and performance in athletes. 29 Results
report that athletes who took 500 mg per day of ViNitrox® and making an intense effort, improve physical
capacities:
hyaluronidase 2, are responsible for regulation of the
glycocalyx thickness and hence access of circulating cells
and factors to the endothelial cell membrane and its
receptors. Glycocalyx degradation actually allows for
resynthesis and adaptive chemical modification of itself.
The resynthesis of HA is dependent on the availability of
its sugar substrates, thus linking glycocalyx biology
directly to cellular glucose metabolism. 23 By providing a
direct link between the endothelium and its extracellular matrix, HA contributes to maintaining glycocalyx
integrity.
Evidence indicates a close association between eGCX
deterioration, concomitant loss of HA and the onset of
endothelial dysfunction.24
•
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Optimized physical capacities by delaying the fatigue
barrier by approximately 13%
Two unpublished consumer studies from the manufacturer report: 30
•
70% agree that ViNitrox® reduces muscle fatigue
and cardio-respiratory fatigue
•
ViNitrox® increased individual power during
“clean” exercise from the first intake.
ViNitrox®
ViNitrox® is a unique proprietary
synergistic combination of apple
(Malus pumila) and grape (Vitis
vinifera) polyphenols.
ViNitrox® antioxidants
help support a healthy
eGCX. The grape seed,
peels and juice in ViNitrox® are from French vineyards
and contain high levels of antioxidant polyphenols
including oligomeric proanthocyanidins (OPCs) and
resveratrol.25
ViNitrox® helps improve nitric oxide by improving eNOs
or endothelial nitric oxide synthase). In vitro and ex vivo
studies report ViNitrox® increases eNOs activation by
43% and NO production by 24%.26 Furthermore an in
vivo study reports a decrease of 74% of oxidative stress
and a minimum guaranteed ORAC value of 6000 units.27
Polyphenols from grapes/apples are also reported to
improve mitochondrial dysfunction, cellular apoptosis,
sirtuin expression in endothelial cells and ultimately
improve performance by decreasing muscle and
cardio-respiratory fatigue.28
Increases physical training time by approximately
10%
Vascaman™
Vascaman™ is the phytocompound
Acemannan (or beta-(1,4)-acetylated
mannan). Acemanan is the active
ingredient of the organic inner leaf
gel of the aloe vera plant (Aloe
barbadenis Miller).31 Vascaman™
has the following properties to
separate it from any competition as
a nutraceutical: 32
•
HIGHEST Total Aloe PolyAcetyl Mannans – On
Average 18%
•
HIGHEST Immunomodulatory Aloe PolyAcetyl
Mannans < 400 KDa
•
HIGHEST Bioavailable Aloe PolyAcetyl Mannans