Catalyst Portfolio Paperturn 3.17.25 - Catalog - Page 1 - Catalog - Page 36
+207%
0%
+106%
100%
+81%
Relative induction time increase
200%
0.2%
Mixed tocopherols
0.2%
Cosphaderm® Tocopharin
0.68%
Cosphaderm® Tocopharin
Figure 2: Determination of oxidation stability via Rancimat test at 100 °C according to method §64 LFGB L13.00-38:2010-01. Relative increase in
induction time compared to untreated sunflower oil by 0.2% mixed tocopherols (green), 0.2% Cosphaderm® Tocopharin (blue) or 0.68% Cosphaderm®
Tocopharin (red).
In order to substantiate the antioxidant effect of
Cosphaderm® Tocopharin in the skin, an in vitro
study was conducted in which the amount of reactive oxygen species in human keratinocytes
was measured. These skin cells were incubated
with the test substances for 24 hours, exposed
to UV irradiation for induction of ROS formation
and subsequent measurement of decreased ROS
formation. The positive effect of Cosphaderm®
Tocopharin becomes obvious in comparison to
the reference materials mixed tocopherols and
the synthetic standard antioxidant Butylated
Hydroxytoluene (BHT), which were each used at
the same concentration in the assay (Fig. 1). The
synthetic antioxidant BHT and the mixed tocopherols display comparable performance at
0.003%. At the same application concentration,
Cosphaderm® Tocopharin can significantly decrease the formation of ROS through UV irradiation.
Compared to the untreated sample, Cosphaderm®
Tocopharin can reduce the ROS level by 26%.
These results confirm a striking skin-cell-protecting
effect of Cosphaderm® Tocopharin against UVinduced oxidation processes.
Tocopherol and Carnosic Acid, only low concentrations of Cosphaderm® Tocopharin starting from
0.1% are required to ensure excellent product
protection. The outstanding effectiveness of
Cosphaderm® Tocopharin in protecting oils against
rancidity was demonstrated in Rancimat tests
in comparison with the industry standard mixed
tocopherols (Fig. 2). Relative change compared
to untreated sunflower oil when using the antioxidants is shown. The improvement in oxidation
stability with 0.2% mixed tocopherols is evident.
At the same concentration, a further 25% increase in stability can be achieved with Cosphaderm®
Tocopharin. At equivalent quantity of tocopherols,
the influence of Carnosic Acid is clearly highlighted. The corresponding application concentration of 0.68% Cosphaderm® Tocopharin leads to a
tripling of the oxidation protection performance.
The new antioxidant blend
Cosphaderm® Tocopharin therefore is the
perfect choice for protecting formulations
and the skin itself from oxidative stress.
ADDITIONAL BOOST FOR
TOCOPHEROLS IN PRODUCT
PROTECTION
Cosmetic formulations containing oils must be
protected against visual and odour impairment
caused by oxidative processes. Thanks to the
combination of the two antioxidant substances
1
cosphatec.com/cosphaderm-tocopharin
Loussouarn, M. et al., Plant Physiol. 2017, 175(3), 1381-1394.
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