الإنتاج البحثي لأعضاء هيئة التدريس بالكلية V.8 - Flipbook - Page 193
(4) Slimeni, O., Zaiter, A., Chaimbault, P., Salih, R. O., Pokrywka, A., Sellami, S., Bragazzi,
N., & Sellami, M. (2021). Beneficial and Detrimental Effects of Antioxidants Use in Sports: How
is it Balanced?. Current Nutraceuticals, 2(3), 174–191.
https://doi.org/10.2174/2665978602666210223150102
This review aims to summarize the fundamental classes of antioxidants, the utilization of the
supplement with antioxidants as ergogenic benefits in exercise and sport, the efficiency, and the
consequence of their chronic uses. Antioxidants have been used for a long time in different sports
disciplines and at all degrees of rivalry. The supplement with antioxidants anticipates muscle
damage by reducing immune dysfunction, inflammation, and fatigue syndrome for athletes.
Subsequently, antioxidant supplementation will improve the physical performances and health of
athletes. Polyphenol compounds as incredible antioxidants that are abundant in numerous plants.
The consumption of antioxidants could be hazardous whenever taken in high dosages. Researchers
found that overdoses may cause undesirable symptoms and might grow the risk of death
(5) Sellami, M., Bragazzi, N., Prince, M. S., Denham, J., & Elrayess, M. (2021). Regular, Intense
Exercise Training as a Healthy Aging Lifestyle Strategy: Preventing DNA Damage, Telomere
Shortening and Adverse DNA Methylation Changes Over a Lifetime. Frontiers in Genetics, 12.
https://doi.org/10.3389/fgene.2021.652497
Exercise training is one of the few therapeutic interventions that improves health span by delaying
the onset of age-related diseases and preventing early death. The length of telomeres, the 5'TTAGGG n -3' tandem repeats at the ends of mammalian chromosomes, is one of the main
indicators of biological age. Telomeres undergo shortening with each cellular division. This
subsequently leads to alterations in the expression of several genes that encode vital proteins with
critical functions in many tissues throughout the body, and ultimately impacts cardiovascular,
immune and muscle physiology. The sub-telomeric DNA is comprised of heavily methylated,
heterochromatin. Methylation and histone acetylation are two of the most well-studied examples
of the epigenetic modifications that occur on histone proteins. DNA methylation is the type of
epigenetic modification that alters gene expression without modifying gene sequence. Although
diet, genetic predisposition and a healthy lifestyle seem to alter DNA methylation and telomere
length (TL), recent evidence suggests that training status or physical fitness are some of the major
factors that control DNA structural modifications. In fact, TL is positively associated with
cardiorespiratory fitness, physical activity level (sedentary, active, moderately trained, or elite) and
training intensity, but is shorter in over-trained athletes. Similarly, somatic cells are vulnerable to
exercise-induced epigenetic modification, including DNA methylation. Exercise-training load,
however, depends on intensity and volume (duration and frequency). Training load-dependent
responses in genomic profiles could underpin the discordant physiological and physical responses
to exercise. In the current review, we will discuss the role of various forms of exercise training in
the regulation of DNA damage, TL and DNA methylation status in humans, to provide an update
on the influence exercise training has on biological aging.
(6) Sellami, M., Al-Muraikhy, S., Al-Jaber, H., Al-Amri, H., Al-Mansoori, L. J. R. J., Mazloum,
N. A., Donati, F., Botre, F., & Elrayess, M. (2021). Age and sport intensity-dependent changes in
cytokines
and
telomere
length
in
elite
athletes.
Antioxidants,
10(7).
https://doi.org/10.3390/antiox10071035
Background: Exercise-associated immune response plays a crucial role in the aging process. The
aim of this study is to investigate the effect of sport intensity on cytokine levels, oxidative stress
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