iM3 Catalogue - Europe - Flipbook - Page 74
iM3 | The Global Name in Veterinary Dentistry
SYNERGY - Pure Synthetic Bone Graft
Effective Bone Graft Substitute
Perfect for dental applications. Ideal auto or allograft
extender.
CO N S U M A B L E S
Radiodense
Clearly evident on radiographic images, allowing
visualisation of bone graft placement.
Affordable
The price conscious solution for periodontal or orthopedic
bone void filling.
Innovative, Convenient Packaging
Cat. Code
Synergy Mini Vials 4 cc (8 x 0.5 cc doses) SD8X05CC
Synergy is an advanced biosynthetic bone graft comprised of
calcium phosphates that occur naturally in real bone. It is
a biphasic combination of β-Tricalcium Phosphate (β -TCP)
and Hydroxyapatite (HA).
Advanced Formulation - Biphasic Synergy is composed of
biocompatible β-TCP and HA1 sintered together. The ratio is
optimized for swift transformation into new bone throughout
the graft.
85% resorbable β -TCP
15% structurally stable HA
Balanced Remodelling - Synergy works with the body in
2 integrated phases:
Phase 1: β-TCP simultaneously resorbs as new bone is
formed2, remodeling throughout the graft
Phase 2: HA microparticles slowly resorb, providing an
osteoconductive scaffold
Cancellous-like, Osteoconductive Morphology - Synergy’s
structure is the architectural equivalent of cancellous bone.
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Interconnected porous structure encourages stem
cell migration, proliferation and differentiation into
osteoblasts2
Provides for an adequate flow of nutrients to enhance
new bone formation3
These intelligent bioactive materials have the proven ability
to stimulate bone formation.3 The β -TCP quickly releases
calcium ions4 that cause clotting and release of plateletderived growth factors. This cascade of mineral release
and blood clotting provides the perfect environment for
stimulation of bone healing.
The cancellous-like porosity and surface structure encourage
inward cell migration. As the β -TCP resorbs more space
is created to support angiogenesis and bone formation1.
The micro particles of HA provide a more long lasting
osteoconductive structure.
Indications:
Filling, bridging and/or reconstruction of non weightbearing bony defects.
Void filling / Extraction sites
Periodontal pockets / Other bone loss
Fracture repair
Cysts / Other osseous defects
References:
1. Farina et al., In vivo behaviour of two different biphasic
ceramic implanted in mandibular bone of dogs. J Mater
Sci: Mater Med 19:1565-1573, 2008
2. Spivak JM, Hasharoni A. Use of hydroxyapatite in spine
surgery. Eur Spine J. 10: S197-S204, 2001
3. Habibovic P, de Groot K. Osteoinductive biomaterials
–properties and relevance in bone repair. J Tissue Eng
Regen Med. 1: 25-32, 2007
4. Daculsi et al., Transformation of biphasic calcium phosphate ceramics in vivo: ultrastructural and physicochemical characterization. J Bio Mat Res 23:883-94,1989
