iM3 | The Global Name in Veterinary DentistrySYNERGY - Pure Synthetic Bone GraftEffective Bone Graft SubstitutePerfect for dental applications. Ideal auto or allograftextender.CO N S U M A B L E SRadiodenseClearly evident on radiographic images, allowingvisualisation of bone graft placement.AffordableThe price conscious solution for periodontal or orthopedicbone void filling.Innovative, Convenient PackagingCat. CodeSynergy Mini Vials 4 cc (8 x 0.5 cc doses) SD8X05CCSynergy is an advanced biosynthetic bone graft comprised ofcalcium phosphates that occur naturally in real bone. It isa biphasic combination of β-Tricalcium Phosphate (β -TCP)and Hydroxyapatite (HA).Advanced Formulation - Biphasic Synergy is composed ofbiocompatible β-TCP and HA1 sintered together. The ratio isoptimized for swift transformation into new bone throughoutthe graft. 85% resorbable β -TCP 15% structurally stable HABalanced Remodelling - Synergy works with the body in2 integrated phases:Phase 1: β-TCP simultaneously resorbs as new bone isformed2, remodeling throughout the graftPhase 2: HA microparticles slowly resorb, providing anosteoconductive scaffoldCancellous-like, Osteoconductive Morphology - Synergy’sstructure is the architectural equivalent of cancellous bone.www.im3vet.eu Interconnected porous structure encourages stemcell migration, proliferation and differentiation intoosteoblasts2 Provides for an adequate flow of nutrients to enhancenew bone formation3These intelligent bioactive materials have the proven abilityto stimulate bone formation.3 The β -TCP quickly releasescalcium ions4 that cause clotting and release of plateletderived growth factors. This cascade of mineral releaseand blood clotting provides the perfect environment forstimulation of bone healing.The cancellous-like porosity and surface structure encourageinward cell migration. As the β -TCP resorbs more spaceis created to support angiogenesis and bone formation1.The micro particles of HA provide a more long lastingosteoconductive structure.Indications: Filling, bridging and/or reconstruction of non weightbearing bony defects. Void filling / Extraction sites Periodontal pockets / Other bone loss Fracture repair Cysts / Other osseous defectsReferences:1. Farina et al., In vivo behaviour of two different biphasicceramic implanted in mandibular bone of dogs. J MaterSci: Mater Med 19:1565-1573, 20082. Spivak JM, Hasharoni A. Use of hydroxyapatite in spinesurgery. Eur Spine J. 10: S197-S204, 20013. Habibovic P, de Groot K. Osteoinductive biomaterials–properties and relevance in bone repair. J Tissue EngRegen Med. 1: 25-32, 20074. Daculsi et al., Transformation of biphasic calcium phosphate ceramics in vivo: ultrastructural and physicochemical characterization. J Bio Mat Res 23:883-94,1989
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