Master ReVasca Monograph 6.2.24 - Paper - Page 5
REVASCA™ PHYSICIAN MONOGRAPH
— Why ReVasca™? —
The search for measures to protect the eGCX from degradation is a hot topic in scientific research. Clinicians have
used conventional therapies to try to support the eGCX,
including corticosteroids, antithrombin agents, nitric
oxide, TNF-alpha inhibitors, and antibiotics among
others.13
Several classes of glycocalyx-supportive compounds in
ReVasca™ provide levels of support to Restore, Regenerate, Protect the glycocalyx. These compounds include:
•
However, all these modalities can produce unwanted side
effects, adverse reactions, damage the sensitive GUT
microbiome and can deplete essential nutrients from the
body.
What is an effective and non-invasive way to support the
eGCX without the side effects of drug therapy? After over
a decade of research into supporting and improving the
eGCX and the facts are in – a proprietary nutraceutical
called ReVasca™.
Multiple clinical studies have reported on the effectiveness of ingredients in ReVasca™ and the synergistic ability
of these compounds in preserving endothelial glycocalyx
structure and function.14, 15
Polysaccharides from both seaweed and aloe support
immunoregulation, including improving function of
macrophages, T- lymphocytes, antigen-presenting
cells, mast cells, neutrophils, and natural killer cells
(NK).
•
Amino sugars –hyaluronic acid (HA) is a component of
the endothelial glycocalyx and when taken internally
it is able to repair and stabilize the glycocalyx, and it
enables the production of more glycocalyx. HA in
ReVasca™ 1) binds to the endothelial glycocalyx at
sites of damage, and 2) increases the fluid shear stress
sensitivity of the endothelial glycocalyx, which
enables the cells of the vessel wall to produce more
glycocalyx polysaccharides.
•
Antioxidants - antioxidants protect the polysaccharides of the eGCX from additional damage and breakdown. The antioxidants used in ReVasca™ are polyphenols and flavonoids found in grape and apple
concentrates. Also included is SOD (super oxide
dismutase) from Soybean and Catalase (from Aspergillus fungus), both necessary enzymes in antioxidant
pathways and necessary for proper antioxidant
support. SOD binds to the negative charges on the
glycocalyx polysaccharides, and allows for strong
antioxidant activity close to the endothelial cell
membrane.
ReVasca™ is the result of over 15 years of research by the
Glycocalyx Research Institute scientists who are the
leading researchers in this field globally.
ReVasca™ helps optimize capillary
structure and function, which allows
those small vessels to exchange
oxygen and carbon dioxide, nutrients, and waste more efficiently,
ultimately preserving the endothelial glycocalyx and improving the
health and longevity of the individual.
There are only 1% of large vessels
(arteries/veins) in the body, the rest
are capillaries, so preserving their
health is of paramount importance.
Polysaccharides - long sugar chains from the brown
seaweed (Laminaria japonica) – called fucoidin - can
interact with proteins and other molecules of the
glycocalyx to restore its protective structure; polysaccharides enable repair of damage to the glycocalyx.
Polysaccharides from Aloe, called acemannan, are also
included in the formula. Acemannan is reported to
decrease inflammation, improve immunity, support
GUT microbiome and improve cardiovascular and
metabolic issues along with antitumor activity.16